Shtakh Aleksandr Filippovich, Candidate of medical sciences, head of the sub-department of obstetrics and gynecology, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: firstname.lastname@example.org
Novikova Yuliya Andreevna, Assistant, sub-department of obstetrics and gynecology, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: email@example.com
Background. To study the differences in the content of PAPP-A in serum during the first prenatal screening in pregnant women followed by delivery before and after 37 weeks of pregnancy and the relationship of these differences with the characteristics of history.
Materials and methods. The age of the patients, history (number of pregnancies, number of births, presence of preterm birth), the level of PAPP-A in the serum of the pregnant woman and the period of pregnancy at the time of the first stage of prenatal screening and at the time of delivery were retrospectively evaluated in 179 puerperas. The main group consisted of 108 patients who gave birth at the time of pregnancy up to 37 full weeks, the comparison group consisted of 71 patients who gave birth at full-term pregnancy. According to the number of pregnancies and births in the history in each group, subgroups were identified: primiparous and recurrent.
Results. In the main group, PAPP-A was significantly lower than in the comparison group (p = 0,002). Among the recurrent pregnant women of the main group there were also significantly lower values of serum PAPP-A at the first prenatal screening than in the comparison group (p = 0,046). Such differences were observed among the primiparous of both groups (p = 0,017).
Conclusion. The content of PAPP-A in the blood serum at the first stage of prenatal screening is significantly lower in the first-born, who will be delivered before full term. The presence of preterm birth in the history led to a significant decrease in RARP-A in the blood during subsequent pregnancy.
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